FIRST YEAR BIOCHEMISTRY: PROTEINS & ECM

PROTEINS

 

1 SEQ from it

·         Its v imp for viva 

·         Lippincott Chap1,2

·         Chap 1 is very basic, just give it a read. 

·         Chap 2 is v imp

Important questions:

·         properties of peptide bond

·         sequencing of peptide bond 

·         Secondary structure of proteins (v imp)

·         what are motifs?

·         interactions stabilizing tertiary structure (proff)

·         what are chaperons and their role?

·         Amyloid disease? Alzheimer?

·         Satya chap 4 (only following topics)

·         Classification of amino acids

·         classification of proteins

·         nonstandard amino acids and table 4.2

·         Separation techniques from Mushtaq (chromatography resins are part of past papers of proff)

·         rest of the topics will be covered from

·         Also do plasma proteins 

·         Functions of all proteins are v imp

 

ECM

 

·         Lippincott chap 4 mainly and a few things from Satya

·         diff b/w collagen and elastin (harper)

·         table 4.2 (Lippincott imp)

·         biosynthesis of collagen (do see the role of enzymes hydroxylases, lyases, oxidases, peptidases etc. in each step)

·         collagen diseases (v imp)

·         a scenario can come from disease scurvy (swollen gums, severe joint pain, shortness of breath, bruises, capillary fragility)

·         Structure of elastin (sendups)

·         Marfan syndrome v imp (came in our prof)

·         role of antitrypsin

·         William syndrome (Satya)

·         Fibrillin, laminin, fibronectin (Satya imp)

·         Also do laminin and fibronectin from Harper

·         Diff b/w collagen and elastin from Harper